|
T17183 |
TY-52156
|
|
S1P Receptor
,
LPL Receptor
|
|
TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM). |
|
T2000 |
AM095
|
|
LPA Receptor
,
LPL Receptor
|
|
AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively. |
|
T12821 |
S1PR1 modulator 1
|
|
LPL Receptor
|
|
|
|
T9464 |
CYM50358
|
|
LPL Receptor
|
|
N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50 of 25 nM. |
|
T7360 |
GSK2018682
|
|
S1P Receptor
,
LPL Receptor
|
|
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively). |
|
T7393 |
ONO-7300243
|
|
LPA Receptor
,
LPL Receptor
|
|
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM). |
|
T6347 |
Ki16198
|
|
LPA Receptor
,
LPL Receptor
|
|
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activ... |
|
T15629 |
JTE-013
|
|
Apoptosis
,
S1P Receptor
,
LPL Receptor
|
|
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 nM, respectively). |
|
TQ0227 |
Etrasimod
|
APD334 |
S1P Receptor
,
LPL Receptor
|
|
Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells). |
|
T22834 |
H2L 5765834
|
|
LPA Receptor
,
LPL Receptor
|
|
H2L 5765834 is a lysophosphatidic acid receptors antagonist |
|
T22703 |
CYM-5520
|
CYM 5520 |
S1P Receptor
,
LPL Receptor
|
|
CYM-5520 is a noncompetitive allosteric agonist of S1P2 |
|
T15032 |
CYM50308
|
|
S1P Receptor
,
LPL Receptor
|
|
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more sel... |
|
T28169 |
NIBR-0213
|
NIBR 0213 |
LPL Receptor
|
|
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis. |
|
T22101 |
ML-031
|
|
S1P Receptor
|
|
ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay. |
|
T6108 |
Ki16425
|
Debio 0719 |
LPA Receptor
,
LPL Receptor
|
|
Ki16425 (Debio 0719) is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively. |
|
T12086 |
Mocravimod hydrochloride
|
KRP-203 |
Others
,
LPL Receptor
|
|
|
|
T3258 |
Ponesimod
|
ACT-128800 |
S1P Receptor
,
LPL Receptor
|
|
Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity. |
|
T9699 |
TAK-615
|
|
LPA Receptor
|
|
TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors. |
|
T4031 |
S1p receptor agonist 1
|
S1p-receptor-agonist-1 |
S1P Receptor
,
LPL Receptor
|
|
S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist. |
|
T15031 |
CYM50260
|
|
Others
,
LPL Receptor
|
|
CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R. |
|
T2026 |
CYM5442
|
|
S1P Receptor
,
LPL Receptor
|
|
CYM5442 is an S1P agonist, targeting to Sphingosine. |
|
T6403 |
Siponimod
|
BAF-312 |
S1P Receptor
,
LPL Receptor
|
|
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for S1P1 and S1P5 receptors exhibi... |
|
T10305 |
Amiselimod hydrochloride
|
MT-1303 hydrochloride |
S1P Receptor
,
LPL Receptor
|
|
Amiselimod hydrochloride (MT-1303 hydrochloride) is a sphingosine 1-phosphate receptor-1 (S1P1) modulator. |
|
T22102 |
ML-178
|
CYM50179 |
Others
|
|
ML-178, a dichlorobenzene, is a potent and selective agonist of sphingosine-1-phosphate receptor 4 (S1PR4), with an EC50 of 46 nM, and has no effect on other S1P receptors at a concentration of 25 μM. |
|
T6923 |
Ozanimod
|
RPC-1063 |
S1P Receptor
,
LPL Receptor
|
|
Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclero... |
|
T4016 |
BMS-986020
|
AM152,BMS986020 |
LPA Receptor
,
LPL Receptor
|
|
BMS-986020 (AM152) is a selective antagonist of LPA1. |
|
T3961 |
CYM-5541
|
CYM 5541,ML249,CID-17253208 |
S1P Receptor
,
LPL Receptor
|
|
CYM-5541 (ML249) is a selective and allosteric S1P3 receptor agonist. |
|
T2171 |
SEW2871
|
SEW2871 |
S1P Receptor
,
LPL Receptor
|
|
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an... |
|
T21654 |
1-Oleoyl lysophosphatidic acid sodium
|
1-Oleoyl lysophosphatidic acid sodium salt |
LPA Receptor
|
|
1-Oleoyl lysophosphatidic acid sodium (1-Oleoyl lysophosphatidic acid sodium salt) salt is an Endogenous agonist of LPA1 and LPA2 |
|
T2539 |
Fingolimod hydrochloride
|
Fingolimod (FTY720) HCl,FTY720 |
TRP/TRPV Channel
,
S1P Receptor
,
PAK
,
LPL Receptor
|
|
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells). |
|
T4278 |
AM966
|
|
LPA Receptor
,
LPL Receptor
|
|
AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release. |
|
T10293 |
AM095 free acid
|
|
LPA Receptor
,
LPL Receptor
|
|
AM095 (free acid) is a potent LPA1 receptor antagonist (IC50s: 0.98 and 0.73 μM for recombinant human or mouse LPA1). |
|
T22697 |
CS 2100
|
1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid |
S1P Receptor
|
|
CS 2100 (1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid) is an S1P1 agonist. |
|
T6085 |
PF-543
|
Sphingosine Kinase 1 Inhibitor II,PF 543 |
Apoptosis
,
S1P Receptor
,
Autophagy
,
LPL Receptor
|
|
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM. |
|
T8840 |
PF-543 hydrochloride
|
PF-543 |
Apoptosis
,
S1P Receptor
,
Autophagy
,
LPL Receptor
|
|
PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. |
|
T17237 |
VPC 23019
|
|
S1P Receptor
,
LPL Receptor
|
|
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively). |
|
T9199 |
GLPG2938
|
1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea |
S1P Receptor
,
LPL Receptor
|
|
GLPG2938 (1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea) is a potent and selective antagonist of S1P2. |
|
T3148 |
MK-571 sodium
|
L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid |
Leukotriene Receptor
,
LTR
|
|
MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ... |
